I tried building the DisOrder GUI, Disobedience, against GTK+ OS X (i.e. native GTK+ support, no X11 required).
Having the menu bar in the window rather than in the normal OS X menu bar is rather weird, but presumably that's fixable. It doesn't produce an application bundle yet either; it might be worth waiting until the GTK+ libraries are more stable before attempting that. Drag and drop is the only thing I've found that doesn't work so far.
